D-mannose: a key ingredient to UTI prevention

July 11, 2017 Uqora Staff

Can D-mannose, a sugar found naturally in fruit, help prevent UTIs? 
d-mannose occurs naturally in fruit
When it comes to UTI prevention, cranberry juice has long been the darling. But if you've done your research then you may have heard about another option — D-mannose. D-mannose is a sugar that occurs naturally in fruits like peaches and apples, and it’s transforming UTI prevention. 
Although research around D-mannose is still nascent, there is growing evidence to validate that D-mannose is a powerful substance when it comes to UTI prevention. 
How does it work?
D-mannose targets E. Coli, the bacteria responsible for 90% of UTIs. But it doesn’t kill E. coli, it instead acts as a competitive inhibitor, meaning it attracts and binds with E. coli so that the bacteria can be occupied and safely rinsed, preventing it from binding with your urinary tract instead. 
What do the studies say? 
In a 308 subject, randomized clinical trial, D-mannose supplementation was compared to control over a 6-month period. Those without D-mannose supplementation were 4 times as likely to develop a UTI over a 6-month period. In the D-mannose group, 15 individuals developed a UTI in that 6 month period. In the control group, those not taking D-mannose, 59 developing a UTI in that same time period (1). In a separate study, Bacteriuria (the presence of UTI-causing bacteria in the urine) was measured over a period of 9 days in rats that were administered a solution containing 10% D-mannose. In the urine, researchers observed that the E. coli came out adhered to the D-mannose. The research strongly demonstrated that “D-mannose can significantly reduce bacteriuria within 1 day” (2). 
Are there side effects? 
D-mannose is recognized as safe, although some people report minor side effects like bloating and loose stool, according to WebMD. Relative to the list of side effects associated with the other effective prevention option, prophylactic antibiotics, these side effects are minimal. With continual antibiotic consumption, side effects can range from rashes to diarrhea, to nausea and yeast infections. Not to mention the long-term risk of antibiotic resistance over time. 
How can you use D-mannose most effectively?
There are a few things to consider—first is proper dosage. In order to get the maximum benefit out of D-mannose, you need at least 2g of D-mannose in any serving. Additionally, consider how important hydration is in this process. If you are not hydrated enough to pass urine than D-mannose cannot work its magic.
Uqora has taken all of these factors into account. It includes the exact dosage of D-mannose that was clinically proven to reduce UTIs by as much as 75%. Since you need to mix Uqora with a glass of water, it does double duty in ensuring you are hydrated. Finally, Uqora doesn’t leave the whole job up to D-mannose. Although D-mannose is clearly a key player, it also leverages several other active ingredients that each play an important role, from antibacterial properties to immune system function and electrolyte replenishment, Uqora works the task from several angels. 
Citations: 
1. Altarac, S and1,Papeš, D. “Use of d-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in women.” BJU International, Vol. 113, Issue 1. 2014.
2. Michaels, EK, et al. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Urological Research, Vol. 11, Issue 2. 1983.


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