It is unlikely that the amount of D-Mannose in Uqora products is substantial enough to cause clinically significant changes in blood sugar.
Regardless, the risk vs. benefit of our products should be considered prior to use in diabetic patients, pre-diabetic patients, or those at risk for developing gestational diabetes. The following is a brief description of the way D-Mannose is metabolized in the body, and how it may or may not contribute to elevated blood sugar:
D-Mannose occurs naturally in plants and animals. It is found in small amounts in fruits such as oranges, apples and peaches, as well as in human blood plasma. D-Mannose is absorbed through the intestines, transported to and metabolized within our cells, and finally excreted in urine.
Studies on the metabolism of Mannose have shown that a Mannose bolus dose of <0.2g/Kg body weight increases blood-mannose concentration 3-fold, without affecting blood glucose concentration. For reference, this is a much higher dose than any patient would receive when taking Uqora products. Currently, there are no reports of adverse effects of D-Mannose in humans. This study suggests that dietary ingestion of reasonable doses of D-Mannose (including the amount in Uqora products) would not alter blood sugar in a clinically significant manner.
However, conflicting studies on pregnant women with pre-existing diabetes showed elevated mannose levels in their blood and amniotic fluids, which correlated with high blood glucose concentrations. This particular study suggests that Mannose levels may affect glucose levels in susceptible patients (ex: pregnant women with pre-existing diabetes). Due to these conflicting results, it is still recommended that patients with any concerns for their blood sugar speak to their physician before using Uqora products.