Defend

1708 reviews

Cleanse biofilm & support bladder wall integrity.

Includes 1 month supply (take daily).

Saves you 15%

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Why Defend?

Defend is one part of our 3-part proactive regimen, recommended for anyone impacted by urinary health 3 times or more a year. Defend cleanses biofilm, which helps to keep the urinary tract clear on a day-to-day basis. It also supports bladder wall integrity. You can take Defend by itself, but we recommend everyone looking for better urinary health also take Flush (our drink mix). Bundle the two here.

Antibiotic-free

Antibiotic-free

Gluten-free

Gluten-free

Find out more about Defend

All about Defend

Cleanse biofilm and support bladder wall integrity

  • Mechanism research on the ingredients in Defend shows their ability to cleanse biofilm. Defend also supports bladder wall integrity. With these two functions, Defend helps to keep your bladder clean in the face of hard-to-pinpoint things like stress, hormonal changes and holding your bladder.

  • Biofilm is a collection of microorganisms bound together that attaches to surfaces, like the bladder wall. Mechanism research on the ingredients in Defend shows their ability to clean biofilm.

  • Each bottle includes a 1-month supply (60 capsules). Take 2 capsules together with water daily.

Defend's science and ingredients

Uqora Defend includes multiple active ingredients, which all play an important role:

Piperine is the “active” compound in black pepper. Oddly enough, Piperine can increase the bioavailability of curcumin by 2,000%! Typically, curcumin has poor bioavailability, meaning our bodies don’t absorb the ingredient well on its own. Uqora Defend includes black pepper powder in a small dose to enable our bodies to better absorb curcumin.

Curcumin is the “active” compound in turmeric, a flowering plant commonly used as a spice that is a member of the ginger family. Curcumin gives Uqora Defend its yellowish color. Biofilm can build-up in the urinary tract and curcumin (along with the polyphenols from green tea) has been shown to cleanse biofilm in preliminary laboratory research. Curcumin is also commonly heralded for having anti-inflammatory benefits. The curcumin in Uqora Defend is extracted from the turmeric root.

We recommend talking with your physician if you're pregnant, nursing, take blood thinners or have a history of liver or gallbladder issues. If you take blood thinners, curcumin, an ingredient in Defend, may cause additional blood thinning.

D-Mannose is a type of carbohydrate that occurs naturally in small quantities in many fruits and vegetables including apples, peaches, green beans, and broccoli. Mannose is an important part of human metabolism and urinary health. It has been shown to bind to microorganisms in the urine so that they are unable to attach to the bladder wall.

This extract is mostly (95%) made up of compounds in green tea leaves called catechins, like EGCG and EGC. These have been the subject of much research on various health benefits and have antioxidant properties. Along with curcumin, catechins have been shown to cleanse biofilm in preliminary laboratory research. The green tea extract in Uqora Defend is from the leaves of green tea plants. The caffeine is removed during the extraction process.

42% of all adults in the U.S. are Vitamin D deficient. The vitamin D in Defend is vitamin D3, also called cholecalciferol, the form of vitamin D made by the skin when exposed to sunlight. New research shows that Vitamin D supplementation increases tight junction proteins in the bladder. Essentially, these proteins connect cells that are next to each other.

Hypromellose: This is a vegan polymer used to make the capsule.

Magnesium Stearate: This is a common ingredient in food and supplements to safely keep powders from clumping.

Silica: Also known as silicon dioxide, silica is one of the most common compounds on earth and is found in many plants. Commonly used in food products, in Uqora Defend, silica safely maintains the powder’s texture and keeps it from clumping together.

See supplement facts

Common questions about Defend

Defend is one part of our 3-part proactive regimen. It’s designed to keep the urinary tract clear on a day-to-day basis by regularly cleansing biofilm, and it also supports bladder wall integrity. You can take Defend by itself, but we recommend that everyone looking for better urinary health also take Flush (our drink mix). Bundle the two here.

Defend and Flush contain different active ingredients. While the two products are complementary, they don’t have the same function. Defend is designed to keep the urinary tract clear on a day-to-day basis by regularly cleansing biofilm, and supporting bladder wall integrity. Flush (our drink mix) flushes the urinary tract when you need support, like after sex, with the right amount of effective ingredients. For more support, we recommend bundling the two here.

Yes, Defend, Flush and Promote, are meant to be taken together. All together, these products make up our Complete Regimen - our most popular product bundle. Taking all three products together provides you maximum urinary support. Flush (our drink mix) flushes the urinary tract, Defend cleanses biofilm from the urinary tract and supports bladder wall integrity, and Promote maintains healthy vaginal bacteria. Get the Complete Regimen here.

The recommended daily upper limit for vitamin D is 4000 IU. Most vitamin D supplements have <2000 IU, and Uqora Defend now includes 1500 IU. So, most people should be in the clear, but if you are currently taking other vitamin D sources be sure to check the volume. We've included that amount to be close to the clinical research amounts but not have a full 2000 IU in case people are supplementing with vitamin D that goes up to 2000 IU to stay at a lower dosage of 3,500 per day.

Uqora Defend is not vegan because the vitamin D is sourced from sheep's wool. We chose this source because it is the same version used in clinical research, and we wanted to ensure the maximum efficacy. We apologize for how this may affect our vegan customers. All of the other ingredients in Defend are vegan, as well as all of the ingredients in Flush and Promote.

From our founder:
I had 8 UTIs in one year…

“I was stuck in the cycle of UTIs for years. I was desperate for a way to get ahead, but was told there was little I could do. This inspired my husband and I to start Uqora, alongside doctors & scientists. Now, we’ve been able to help over 300,000 people and counting. Ready to give us a try?”

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Add Promote for just $14.50!

  • 3 strains of lactobacillus (aka 'good' vaginal bacteria).
  • Key to maintaining healthy vaginal bacteria.
  • Supports a healthy urinary tract.
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See which of our 3 proactive products are right for you

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See which of our 3 proactive products are right for you