Defend & Promote

3688 reviews

Cleanse biofilm and support bladder wall integrity, and help maintain healthy vaginal bacteria.

Contains 1 month supply (1 bottle each, take daily).

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Defend & Promote

Why Defend & Promote?

Defend and Promote are key components of our 3-part proactive regimen. This bundle is recommended for anyone who is impacted by urinary health 3 or more times a year and who is postmenopausal and/or sexually active. Defend cleanses biofilm and supports bladder wall integrity, and Promote helps maintain healthy vaginal bacteria, which is crucial to address vaginal and urinary health. If you're looking for maximum support, we recommend the Complete Regimen which includes Flush, here.

Antibiotic-free

Gluten-free

Find out more about each product in your bundle:

Click to learn about each of them below.

All about Defend

  • Each bottle includes a 1-month supply (60 capsules). Take 2 capsules together with water daily.

  • Mechanism research on the ingredients in Defend shows their ability to cleanse biofilm. Defend also supports bladder wall integrity. With these two functions, Defend helps to keep your bladder clean in the face of hard-to-pinpoint things like stress, hormonal changes and holding your bladder.

  • Biofilm is a collection of microorganisms bound together that attaches to surfaces, like the bladder wall. Mechanism research on the ingredients in Defend shows their ability to clean biofilm.

Defend's science and ingredients

Uqora Defend includes multiple active ingredients, which all play an important role:

Piperine is the “active” compound in black pepper. Oddly enough, Piperine can increase the bioavailability of curcumin by 2,000%! Typically, curcumin has poor bioavailability, meaning our bodies don’t absorb the ingredient well on its own. Uqora Defend includes black pepper powder in a small dose to enable our bodies to better absorb curcumin.

D-Mannose is a type of carbohydrate that occurs naturally in small quantities in many fruits and vegetables including apples, peaches, green beans, and broccoli. D-Mannose is an important part of human metabolism and urinary health. It has been shown to bind to microorganisms and flushes them from the urinary tract.

This extract is mostly (95%) made up of micronutrients in green tea leaves called catechins, like EGCG and EGC. These have been the subject of much research on various health benefits and have antioxidant properties. Along with curcumin, catechins have been shown to cleanse biofilm in preliminary laboratory research. The green tea extract in Uqora Defend is from the leaves of green tea plants.

Turmeric Root Extract (95% Curcuminoids) is the “active” compound in turmeric, a flowering plant commonly used as a spice that is a member of the ginger family. Turmeric Root Extract gives Uqora Defend its yellowish color. Biofilm can build-up in the urinary tract and turmeric root extract (along with the polyphenols from green tea) has been shown to cleanse biofilm in preliminary laboratory research. The curcumin in Uqora Defend is extracted from the turmeric root.


We recommend talking with your physician if you’re pregnant, nursing, take blood thinners or have a history of liver or gallbladder issues. If you take blood thinners, curcumin, an ingredient in Defend, may cause additional blood thinning. Stop use and see your physician if you develop symptoms of liver problems, such as fatigue, jaundice, and dark urine.

42% of all adults in the U.S. are Vitamin D deficient. The vitamin D in Defend is vitamin D3, also called cholecalciferol, the form of vitamin D made by the skin when exposed to sunlight. New research shows that Vitamin D supplementation increases tight junction proteins in the bladder. Essentially, these proteins connect cells that are next to each other.

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Common questions about Defend

Yes, Defend, Flush and Promote, are meant to be taken together. All together, these products make up our Complete Regimen - our most popular product bundle. Taking all three products together provides you maximum urinary support. Flush (our drink mix) flushes the urinary tract, Defend cleanses biofilm from the urinary tract and supports bladder wall integrity, and Promote helps maintain healthy vaginal bacteria. Get the Complete Regimen here.

Defend is one part of our 3-part proactive regimen. It’s designed to keep the urinary tract clear on a day-to-day basis by regularly cleansing biofilm, and it also supports bladder wall integrity. You can take Defend by itself, but we recommend that everyone looking for better urinary health also take Flush (our drink mix). Bundle the two here.

Defend and Flush contain different active ingredients. While the two products are complementary, they don’t have the same function. Defend is designed to keep the urinary tract clear on a day-to-day basis by regularly cleansing biofilm, and supporting bladder wall integrity. Flush (our drink mix) flushes the urinary tract when you need support, like after sex, with the right amount of effective ingredients. For more support, we recommend bundling the two here.

Uqora Defend is not vegan because the vitamin D is sourced from sheep's wool. We chose this source because it is the same version used in clinical research, and we wanted to ensure the maximum efficacy. We apologize for how this may affect our vegan customers. All of the other ingredients in Defend are vegan, as well as all of the ingredients in Flush and Promote.

The recommended daily upper limit for vitamin D is 4000 IU. Most vitamin D supplements have <2000 IU, and Uqora Defend now includes 1500 IU. So, most people should be in the clear, but if you are currently taking other vitamin D sources be sure to check the volume. We've included that amount to be close to the clinical research amounts but not have a full 2000 IU in case people are supplementing with vitamin D that goes up to 2000 IU to stay at a lower dosage of 3,500 per day.

All about Promote

  • Each bottle includes a 1-month supply (30 capsules). Take 1 capsule orally with water daily.

  • When the vaginal microbiome does not have healthy populations of lactobacillus, it can impact the urinary microbiome. To maximally support urinary health, vaginal health needs to be taken into consideration.

  • Not all probiotics are the same. Promote is a vaginal probiotic, not a digestive probiotic. Promote supports the good bacteria that are specific to the vagina. You can take Promote alongside other probiotics you might be taking.

  • Promote includes three specific strains of bacteria, Lactobacillus Acidophilus, Lactobacillus Rhamnosus, and Lactobacillus Reuteri, which live naturally in a healthy vagina. Promote helps maintain this healthy vaginal bacteria, which is a key component of urinary tract health.

Promote's science and ingredients

Uqora Promote includes multiple active ingredients, which all play an important role:

L. Acidophilus, L. Rhamnosus and L. Reuteri are specific types of lactobacillus that live naturally in high concentrations in a healthy human vagina. As part of their metabolism, they release acids that keep the vaginal microbiome balanced. When consumed orally, these bacteria have been shown to travel from the gut to the vagina where they can populate. Promote helps maintain this healthy vaginal bacteria, which is a key component of urinary tract health.

See supplement facts

See caution statements

Common questions about Promote

Yes, Defend, Flush and Promote, are meant to be taken together. All together, these products make up our Complete Regimen - our most popular product bundle. Taking all three products together provides you maximum urinary support. Flush (our drink mix) flushes the urinary tract, Defend cleanses biofilm from the urinary tract and supports bladder wall integrity, and Promote helps maintain healthy vaginal bacteria. Get the Complete Regimen here.

No. Promote is a probiotic designed for vaginal health, not digestive health. Not all probiotics are the same, and there are many different types of lactobacillus, and they live in different parts of the body. The types of lactobacillus in Promote are specific to the vagina.

We’ve included the strains shown to maintain vaginal health and have decided to not include anything extra. Why? Microbiomes are sensitive ecosystems, and we believe it is better to not include strains with unknown impact.

Add Flush for just $12

  • Drink to flush your urinary tract when you need extra support.
  • Gives a boost after things like sex, exercise, travel, or holding your bladder.
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From our founder:
I had 8 UTIs in one year…

“I was stuck in the cycle of UTIs for years. I was desperate for a way to get ahead, but was told there was little I could do. This inspired my husband and I to start Uqora, alongside doctors & scientists. Now, we’ve been able to help over 500,000 people and counting. Ready to give us a try?”

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Defend & Promote Reviews

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Uqora's dietary supplement products are not intended to diagnose, treat, cure or prevent disease. Results may vary.