D-Mannose for UTIs

D-mannose is a natural sugar, found in a lot of fruits, including peaches, apples, oranges and more that helps prevent Urinary Tract Infections (UTIs). When D-mannose makes its way to your urinary tract, it targets E. Coli, the bacteria responsible for 90% of UTIs. Instead of killing E. coli, D-mannose acts as a competitive inhibitor, meaning it attracts and binds with E. coli so that the bacteria can be occupied and safely rinsed, preventing it from binding with your urinary tract instead.

D-mannose is one of the active ingredients in Uqora's products, Uqora Target, and Uqora Control. When combined with other, proven mechanisms, the effect is even greater. All of Uqora's products take a multifold approach against bacteria, combining the power of d-mannose with other clinically proven mechanisms to develop the most effective UTI prevention products available.

D-mannose and UTIs

How do I take d-mannose powder?

D-mannose powder is typically mixed with liquid and taken mixed into a drink. Since hydration is an important component of UTI prevention, it’s helpful to mix d-mannose powder into 8-12 oz of water to also increase hydration.

Uqora includes 2g of d-mannose powder. Mix one packet of Uqora with 8-12 oz of water, and drink it flush out UTI-causing bacteria.

What is mannose?

D-mannose is sometimes called just “mannose.” Both mannose and d-mannose refer to the same ingredient.

What is the best d-mannose dosage?

It depends. Uqora Control is intended for day-to-day maintenance and includes 650 mg of d-mannose. Uqora Target includes 2g of d-mannose, a higher dosage, intended to be drank directly after high-risk activities like sex and exercise when bacteria is much more likely to be introduced to the urinary tract. Clinical research has demonstrated up to a 4x reduction in UTI incidence is a 2g dosage of d-mannose.

What are the d-mannose side effects?

Research has not indicated many side effects, but users have reported loose stool or bloating as possible side effects of d-mannose.

Is D-mannose only for E Coli UTIs, or does it help with UTIs caused by other types of bacteria?

D-mannose adheres specifically with E. coli and 90% of UTIs are caused by E. coli. So d-mannose can help prevent the vast majority of UTIs. However, for the 10% of UTIs that are caused by bacteria other than E. coli, you will need a solution that isn’t just based on E. coli.

Uqora’s product combine bacteria-fighting principals with mechanical principles to give you multifold defense against UTIs.

Uqora Target combines d-mannose with powerful, UTI-fighting ingredients for maximum defense

Uqora's preventive drink mix, Target, takes a multi-layered approach to combine the power of D-Mannose, the immune boosting and UTI fighting benefits of Vitamin C, the gentle diuretic benefits of Vitamin B6 to increase urinary flow and push bacteria out, and finally electrolytes to replace what we lose during urination and boost our immune system (potassium, magnesium, and calcium). So it's true that d-mannose a key component, but it's just one of the factors at play.

You guys... this stuff is a life saver.

"I suffered from CHRONIC UTIs and have had some pretty serious repercussions from taking mass amounts of antibiotics. I have not had a UTI since I started taking uqora. I drink it after things that are my triggers (sex in particular) and it stops it in its tracks!"
Lacey, Uqora customer
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Uqora d-mannose

What is the right D-Mannose dosage for UTI prevention? 

What is D-mannose?

D-mannose is a monosaccharide simple sugar that naturally occurs in fruits. However, unlike glucose, it is absorbed much slower so instead of being digested it passes into the bloodstream, is filtered by the kidneys and then enters the bladder.

How does it work?

Coli is the bacteria responsible for 90% of UTIs. When E.coli enters the urinary tract and bladder, it wants to bind to sugar (mannose) that naturally occurs on your bladder walls leading to an infection and UTI.

D-mannose is special because if it is present in your bladder when the E. Coli enters, it will bind to the E. coli before the E. coli can bind to you. The E.coli then gets flushed out when you urinate. Think of the sugar in your bladder like money, D-mannose like decoy money and E. coli like robbers. When robbers break into your house (bladder) instead of going to your real money (sugar on your bladder walls) they are fooled and go towards the decoy money (D-mannose) and get caught.

Backed by Science   

study done in 2014 looked at 308 women with a history of recurrent UTIs. The first group of women received 2 grams of D-mannose powder in 200 ml of water daily for 6 months. The second group of women received 50 mg of Nitrofurantoin, an antibacterial agent, and the third group received a placebo. During the six months, the women receiving the d-mannose had drastically less UTIs than the placebo group and significantly fewer side effects than the group receiving the Nitrofurantoin. The conclusion of the study was that D-mannose significantly reduced the risk of recurring UTIs.

How to use D-mannose effectively

The recommended amount of D-mannose is 2 grams per serving and while D-mannose naturally occurs in fruits you would have to eat an unrealistic amount of fruit every day to get enough D-mannose for it to make a difference.

D-mannose is available in powder form which you could purchase and drink with one glass of water, but if you wanted maximum UTI prevention, you could get your D-mannose with Uqora. One packet of Uqora contains exactly 2 grams of D-mannose in every serving along with other UTI fighting counterparts like Vitamin-B6, Vitamin-C, potassium, magnesium, and calcium. Vitamin-B6 slightly increases urination so all of that E. coli can be flushed out of your system.  Vitamin C is an antioxidant that supports your immune system. Potassium, Magnesium, and calcium are helpful electrolytes. When you drink Uqora not only are you preventing UTIs with the correct dosage of  D-mannose, but you are also getting tons other health benefits.

d-mannose occurs naturally in fruit

Can D-mannose, a sugar found naturally in fruit, help prevent UTIs?

When it comes to UTI prevention, cranberry juice has long been the darling. But if you've done your research then you may have heard about another option — D-mannose. D-mannose is a sugar that occurs naturally in fruits like peaches and apples, and it’s transforming UTI prevention. 
Although research around D-mannose is still nascent, there is growing evidence to validate that D-mannose is a powerful substance when it comes to UTI prevention. 

How does it work?

D-mannose targets E. Coli, the bacteria responsible for 90% of UTIs. But it doesn’t kill E. coli, it instead acts as a competitive inhibitor, meaning it attracts and binds with E. coli so that the bacteria can be occupied and safely rinsed, preventing it from binding with your urinary tract instead. 

What do the studies say? 

In a 308 subject, randomized clinical trial, D-mannose supplementation was compared to control over a 6-month period. Those without D-mannose supplementation were 4 times as likely to develop a UTI over a 6-month period. In the D-mannose group, 15 individuals developed a UTI in that 6 month period. In the control group, those not taking D-mannose, 59 developing a UTI in that same time period (1). In a separate study, Bacteriuria (the presence of UTI-causing bacteria in the urine) was measured over a period of 9 days in rats that were administered a solution containing 10% D-mannose. In the urine, researchers observed that the E. coli came out adhered to the D-mannose. The research strongly demonstrated that “D-mannose can significantly reduce bacteriuria within 1 day” (2). 

Are there side effects? 

D-mannose is recognized as safe, although some people report minor side effects like bloating and loose stool, according to WebMD. Relative to the list of side effects associated with the other effective prevention option, prophylactic antibiotics, these side effects are minimal. With continual antibiotic consumption, side effects can range from rashes to diarrhea, to nausea and yeast infections. Not to mention the long-term risk of antibiotic resistance over time. 

How can you use D-mannose most effectively?

There are a few things to consider—first is proper dosage. In order to get the maximum benefit out of D-mannose, you need at least 2g of D-mannose in any serving. Additionally, consider how important hydration is in this process. If you are not hydrated enough to pass urine than D-mannose cannot work its magic.
Uqora has taken all of these factors into account. It includes the exact dosage of D-mannose that was clinically proven to reduce UTIs by as much as 75%. Since you need to mix Uqora with a glass of water, it does double duty in ensuring you are hydrated. Finally, Uqora doesn’t leave the whole job up to D-mannose. Although D-mannose is clearly a key player, it also leverages several other active ingredients that each play an important role, from antibacterial properties to immune system function and electrolyte replenishment, Uqora works the task from several angels. 
Citations: 
1. Altarac, S and1,Papeš, D. “Use of d-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in women.” BJU International, Vol. 113, Issue 1. 2014.
2. Michaels, EK, et al. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Urological Research, Vol. 11, Issue 2. 1983.