New study addresses why some of us get so many UTIs, while others of us do not

3 min read

urinary tract infections


Why only some people get UTIs

Here’s a scenario: you and your friend have similar hygiene habits, are having a similar amount of sex, and have a similar post-sex and post-workout regimens, yet you get slammed with UTI after UTI, and she is cruising through life oblivious to your suffering. What gives?

Well, it’s complicated. And, according to a study recently conducted by Annals of Translational Medicine, there is a bunch of gaps in our understanding preventing us from fully answering the age-old “why me?” question.

The team of researchers focused their study on the bacteria that most often causes UTIs, Escherichia coli, known collectively as uropathogenic E. coli (UPEC). The aim of the study was to develop a better understanding of the sometimes murky UTI space with the hopes of potentially offering new therapeutic strategies. The team of researchers analyzed 43 strains of E. coli sampled from 14 women with recurrent UTIs. The researchers took a subset of these strains (21) and injected them into mice in order to determine how well the sampled UPEC could infect hosts in a controlled setting.

Ultimately, they found that the bacteria that results varied widely within the same strains. According to Broad Institute's coverage of the study, some mice would develop a UTI from the bacteria known to cause UTIs in the subject group, and some would not:

Additionally, when tested in a second mouse model, some of the UPEC strains that successfully infected the first caused a less severe outcome. Based on these findings, the research team proposed a new pathogenesis model in which each combination of host and UPEC strain is a unique pairing of bacterial urovirulence potential and host susceptibility — and the compatibility of that pairing ultimately determines UTI outcome, including severity.

What does this mean in plain English? The research seems to suggest that you could actually transplant the bacteria that caused your UTI into your friend’s urinary tract, and it might not impact them. In other words, the relationship between your body and the bacteria may be more like a lock-and-key, where the bacteria is the key but it won’t find a fit with every body. So comparing hygiene habits, post-sex routine, etc, could be completely useless. More from Broad Institue:

Thus, two women with UTIs could have infections caused by similar or radically different bacteria, and an E. coli strain that causes a UTI in one person may not make a different person sick at all due to differences in genetics, behavior, medical history, or other environmental features.

It’s too early to draw definitive answers from this research, but the integrative approach is encouraging and the early findings are fascinating.

Uqora was formulated with the understanding that some of us need extra defense, and it doesn't have much to do with hygiene or habits. 

Uqora’s proven and effective formula works in three important ways:

  1. Uqora binds with dangerous bacteria (think: E. coli) to keep that bacteria from binding to your urinary tract. When you urinate, you pee out Uqora that has bound with the dangerous bacteria. 

  2. Uqora includes gentle diuretics to help you pee (and thereby flush out bacteria) more quickly than you could on your own.  

  3. Lastly, Uqora supports your existing natural defenses. Drinking Uqora with water helps flush the liquid, and the added vitamins support immune system function.

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